Why Solace?

Solace results from over 20 years of scientific research and contains the uniquely potent psychobiotic probiotic Lactobacillus plantarum PS128.

It is a natural and effective way to boost your immune system, improve digestive health, and support mental wellness.*

Backed by Science

 

History

Professor Ying-Chieh Tsai, brings over 30 years of industry experience as the lead of our R&D team. Professor Tsai founded Bened Biomedical in 2015 in Taipei, Taiwan, as a spin-out company from National Yang-Ming University (NYMU). It focuses on advanced technologies and products in microbiome-based therapy for neuropsychological, allergic, immunological, metabolic, and aging-related disorders.

Through rigorous research, Professor Tsai discovered and brought to market the first psychobiotic in Asia Lactobacillus plantarum PS128. In 2017, he founded Oryx Biomedical to make Lactobacillus plantarum PS128 available to the United States in the form of Solace. 

 

Gut-Brain Axis

The bacteria in your gut play an important role in your overall health.

The microbes in our gut are often referred to as our “second brain” or “second genome.” Scientists have long known about the link between gut bacteria, inflammation, and the immune system. Now we’ve discovered that gut bacteria can have important mental health implications too.

The gut-brain axis describes how bacteria below interact with the brain above to influence our mood and behavior.

 

Solace with the Psychobiotic PS128

Evidence suggests that certain microbes can have positive mental health benefits. Such bacteria, called psychobiotics, impact the ability to deal with stress, moderate feelings of anxiety, and maintain a balanced mood.

The psychobiotic strain Lactobacillus plantarum PS128 was isolated after testing nearly one thousand strains of bacteria. PS128, a natural bacteria extracted from the mustard green plant, proved especially effective.

Multiple research studies have demonstrated the remarkable properties of PS128. Not only does it strengthen the immune system, but it also benefits mental wellbeing.*

  • Improves immune system
  • Fortifies digestive system
  • Modulates stress
  • Reduces anxiety
  • Promotes healthy, balanced mood

 

Published Research

  • Psychotropic effects in early life-stressed and naïve adult mice (Link)
  • Alteration of behavior in germ-free mice (Link)
  • Immunomodulatory activity (Link)

 

Published Human Clinical Studies

 

Further Research

Additional studies are currently being conducted to continue to document the remarkable benefits of Lactobacillus plantarum PS128 .

Current research is examining the effects of PS128 on

 

Please see links below to Bened Biomedical's current publications

 

Patents awarded in the USA, EU, Japan, Taiwan, and Korea.

 

USA Patent No. US10188684B2

Abstract of invention:

  • The invention provides a method for preventing or treating a functional gastrointestinal disorder in a subject in need thereof that includes a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier.
  • The invention provides a method for preventing or treating visceral hypersensitivity in a subject in need thereof that includes a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier.
  • The invention provides a method for preventing or treating functional abdominal pain, irritable bowel syndrome or constipation in a subject in need thereof that includes a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier.

 

Japanese Patent No. 6035578
European Patent No. EP2937424

Summary of the invention: 

  • The present invention provides protection for a single-isolated lactic acid bacteria - Lactobacillus subspecies plants ( Lactobacillus plantarum subsp. Plantarum ) strain PS128®.
  • The present invention further provides protection for a composition comprising Lactobacillus plantarum subsp. PS128® and a carrier.
  • The present invention provides protection for a method to prevent or treat stress-induced disorders in a subject by administering an effective amount of Lactobacillus plantarum PS128® to the subject
  • The invention also provides protection for a method to prevent or to treat functional gastrointestinal disorders in a subject by administering an effective amount of Lactobacillus plantarum PS128® to the subject.

 

Taiwan Patent No. I623319

Summary of the invention:

  • The present invention indicates that Lactobacillus plantarum PS128® can provide an advantageous effect of treating or preventing circulatory disorders and basal ganglia disorders.
  • The present invention provides a method of treating or preventing movement disorders in an individual comprising administering to the individual an effective amount of Lactobacillus plantarum PS128®.
  • The disorders related to movement disorders of the present invention include: Parkinson's disease, Tourette syndrome, unilateral convulsions, dystonia, psychostimulant addiction, Huntington's disease, and OCD.

 

Korean Patent No. 10-1813881

Summary of the invention:

  • The present disclosure provides an isolated lactic acid bacterium, Lactobacillus plantarum subsp. plantarum PS128® deposited under DSMZ Accession No. DSM 28632. 
  • The present disclosure further provides a composition that comprises Lactobacillus plantarum subsp. plantarum PS128® and a carrier.
  • The present disclosure provides a method for prophylaxis or treatment of a stress-induced disorder in a subject that comprises a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128® to the subject.
  • The present disclosure also provides a method for prophylaxis or treatment of a functional gastrointestinal disorder in a subject that comprises a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128® to the subject.